NEBS PLUS® – Paracetamol & Caffeine BP

Chemical Name: N-acetyl-para-aminophenol (APAP) / Acetaminophen 1,3,7-Trimethylpurine-2,6-dione

Description: NEBS PLUS® is an analgesic (pain killer) and an antipyretic (helps to reduce body temperature). Caffeine is a central nervous system (CNS) stimulant of the methylxanthine class. Caffeine acts by blocking binding of adenosine to the adenosine A1 receptor, which enhances release of the neurotransmitter acetylcholine. Caffeine also increases cyclic AMP levels through nonselective inhibition of phosphodiesterase. Caffeine is a stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. The combination of Paracetamol & Caffeine is used to reduce fever, relief of headache, migraine, neuralgia and rheumatic aches and pains.

— 3×2 Ampoules

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NEBS PLUS® – Paracetamol & Caffeine BP

COMPOSITION

Available in single dosage form:

Nebs Plus® Tablet: Each film coated tablet contains Paracetamol BP 500mg + Caffeine BP 65mg.

PHARMACOLOGY

This is a combination of Paracetamol and Caffeine. Paracetamol has analgesic and antipyretic properties with weak anti-inflammatory activity. Caffeine is an alkaloid which is a theophylline-like xanthine derivative. By intermolecular association with Paracetamol, Caffeine increases the solubility and transmembrane permeation of Paracetamol. In addition, Caffeine increases the pain threshold and tolerance of pain. Caffeine has also an intrinsic power to raise vessel tone in the brain, which provides another benefit to treat migraine and headache.

INDICATION

Nebs Plus is indicated for Headache, Migraine, Toothache, Neuralgia, Feverishness, Period pain, Sore throat, Backache, help to reduce the temperature, Aches and pain of colds and flu

DOSAGE AND ADMINISTRATION

Adult dose: 1-2 tablets every 4-6 hours. Maximum dose: 8 tablets daily.

Child dose: Not recommended for children below 12 years.

SIDE EFFECT

Side effects of paracetamol are usually mild, though haematological reactions including thrombocytopenia, leukopenia, pancytopenia, neutropenia, and agranulocytosis have been reported. Pancreatitis, skin rashes, and other allergic reactions occur occasionally.

CONTRAINDICATION

Paracetamol is contraindicated in patients with severe renal function impairment and hepatic disease (Viral Hepatitis). Known hypersensitivity to paracetamol or caffeine.

PRECAUTION

Paracetamol & Caffeine should be given cautiously in the following cases: In patients with hepatic or renal failure, in patients taking other hepatotoxic medication. Prolonged use of the drug without consulting a physician should be avoided.

USE IN PREGNANCY AND LACTATION

Pregnant mothers should consult with doctors before taking Paracetamol & Caffeine. Paracetamol & Caffeine can be taken whilst breast feeding.

STORAGE

Nebs Plus should be stored in a cool & dry place. Keep away from light and heat. Keep out of the reach of the children.

PACKAGING

Nebs Plus Tablet: Each box contains 10X10’s tablets in blister strip pack.

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