E-HEXIN®– Bromhexine Hydrochloride BP
Composition
Available in two dosage forms:
E-Hexin Tablet: Each tablet contains 16mg Bromhexine.
E-Hexin Suspension: Each 5 ml suspension contains Bromhexine HCl BP equivalent to 4 mg Bromhexine.
Description
Bromhexine is mucolytic agent used for a variety of respiratory conditions associated with increased mucus secretion. It aids in the clearance of excess mucus, improving breathing and reducing cough and most importantly, clearing the sinuses. It is secretolytic, increasing the production of serous mucus in the respiratory tract, which makes the phlegm thinner and less viscous. This contributes to a secretomotic effect, allowing the cilia to more easily transport the phlegm out of the lungs.
Indications
E-Hexin is a mucolytic/mucokinetic expectorant. This drug has been reported change he structure of bronchial secretions and to increase the volume and reduce the viscosity of sputum. It is indicated in the cases of
- Acute and Chronic Bronchitis
- Sinusitis
- Otitis media
- Sjogren’s syndrome
- Post surgical bronchial complications
Dosage and Administration
Bronchitis
Adult: 8 to 16 mg three- four times daily. Children (5-12 Years) 8 mg four times daily Children (below 5 years) 4 mg twice daily Otitis Media 16 mg twice daily
Lower Respiratory Infections 8 mg every eight hours daily Along with Antibiotic
Siogren’s Syndrome 8mg every 8 hours daily (normal dose) 16 mg 8 hours daily (in special case)
Contraindication
Contraindications. Bromhexine is contraindicated for use in patients with known hypersensitivity or idiosyncratic reaction to bromhexine hydrochloride.
Precaution
Since mucolytics may disrupt the gastric mucosal barrier, bromhexine should be used with caution in patients with a history of gastric ulceration. Clearance of bromhexine or its metabolites may be reduced in patients with severe hepatic or renal impairment.
Drug Interaction
When given in combination with Bromhexine the concentrations of Chloramphenicol, Tetracycline of Spramycin in the bronchial secretion are increased and may show symptoms of drug adverse effects of the antibiotics.
Side effects
There are no serious side effects of Bromhexine HCI. However, gastrointestinal side effects may occur occasionally with bromhexine and a transient rise in serum aminotransferase values has been reported. Other reported adverse effects include headache, vertigo (dizziness), sweating and allergic reactions.
Use in pregnancy and lactating
No evidence of ill-effects during pregnancy, but the use of drugs 1st trimester of pregnancy should be observed. Bromhexine HCl is expected to enter breast milk. Therefore, it is not recommended for breastfeeding mothers unless the potential benefits to the patient are weighed against the possible risk to the infant.
Storage
Store tablet and suspension at or below 30°C. Protect from light & moisture. Keep out of the reach of children.
PACKAGING
E-HEXIN Tablet: Each box contains 10 strips of 10 tablets in blister pack.
E-HEXIN Suspension: Each bottle contains 100 ml Suspension.
