EURIX ® – Cefuroxime USP
COMPOSITION
Available in two dosage forms:
EURIX®250 mg Tablet: Each film coated tablet contains Cefuroxime Axetil BP equivalent to Cefuroxime 250 mg.
EURIX® 500 mg Tablet: Each film coated tablet contains Cefuroxime Axetil BP equivalent to Cefuroxime 500 mg.
EURIX® Powder for Suspension: After reconstitution, each 5 ml suspension contains Cefuroxime Axetil BP equivalent to Cefuroxime 125 mg.
MODE OF ACTION
Cefuroxime Axetil is a broad-spectrum second-generation Cephalosporin active against a wide range of Gram-positive and Gram-negative susceptible organisms including many beta-lactamase producing strains. The bactericidal action of cefuroxime axetil results from inhibition of cell wall synthesis by binding to essential target proteins. Cefuroxime has good stability to bacterial beta-lactamases.
INDICATION
Cefuroxime is indicated in the treatment of:
Upper respiratory tract infections: Ear, nose, throat infections such as otitis media, sinusitis, tonsillitis & pharyngitis. Lower respiratory tract infections: Acute & chronic bronchitis & pneumonia. Genitourinary tract infections: Pyelonephritis, cystitis & urethritis. gonorrhea, acute uncomplicated gonococcal urethritis & cervicitis.
Skin & tissue infections: Furunculosis, pyoderma & Impetigo. Lyme disease: Erythema marginatum.
DOSAGE AND ADMINISTRATION
| Infections | Dosage | Duration |
| Tablet
(May be administered without regard to meals) Adolescents & adults (13 years & above) Pharyngitis of tonsillitis Acute bacterial maxillary sinusitis Acute bacterial infection of bronchitis Uncomplicated skin & skin structure infections Lyme Disease Uncomplicated urinary tract infections Gonorrhea Paediatric patients (upto 12 years) (Who can swallow tablets whole) Pharyngitis or tonsilitis Acute otitis media Acute bacterial maxillary sinusitis |
250 mg twice daily 250 mg twice daily 250-500 mg twice daily 250-500 mg twice daily 500 mg twice daily 125-250 mg twice daily 1000 mg once 125 mg twice daily 250 mg twice daily 250 mg twice daily |
5-10 days 10 days 10 days 7-10 days 20 days 7-10 days Single Dose 5-10 days 10 days 10 days |
| Suspension
(Must be administered immediately after meal. Shake the bottle well before each use) Paediatric patients (3 months to 12 years) Pharyngitis or tonsilitis Acute otitis media Acute bacterial maxillary sinusitis |
20 mg/kg/day in two divided doses 30 mg/kg/day in two divided doses 30 mg/kg/day in two divided doses |
5-10 days 10 days 10 days |
CONTRAINDICATION
Contraindicated in patients with known allergy to cephalosporin & having pseudomembranous colitis.
SIDE EFFECT
Generally, Cefuroxime is well tolerated. However, a few side effects like nausea, vomiting, diarrhea, abdominal pain may occur. As with other broad spectrum antibiotics prolonged administration of Cefuroxime Axetil may result in
overgrowth of nonsusceptible microorganisms. Rarely renal dysfunction, pruritus, angioedema, rash and serum sickness like urticaria may appear.
USE IN PREGNANCY AND LACTATION
Pregnancy: Pregnancy category ‘B’. While all antibiotics should be avoided in the first trimester if possible. However,
Cefuroxime has been safely used in later pregnancy to treat urinary infections.
Nursing mother: Cefuroxime is excreted into the breast milk in small quantities. However, the possibility of sensitizing the infant should be kept in mind.
STORAGE
Store tablet and Powder for Suspension at or below 30°C. Protect from light & moisture. Keep out of the reach of children.
PACKAGING
EURIX® 250 mg Tablet: Each box contains 3 Strips of 7 tablets in Alu-Alu blister pack. EURIX® 500 mg Tablet: Each box contains 2 Strips of 7 tablets in Alu-Alu blister pack.
EURIX® Powder for Suspension: Each bottle contains powder for reconstitution of 70 ml suspension.
